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BX471 hydrochloride
CAS No. 288262-96-4
BX471 hydrochloride( BX-471 hydrochloride | BX 471 hydrochloride )
Catalog No. M13882 CAS No. 288262-96-4
BX471 is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 537 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBX471 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBX471 is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.
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DescriptionBX471 is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1; shows 10,000-fold selectivity for CCR1 compared with 28 GPCRs (); displays CCR1 ligands MIP-1α, RANTES, and MCP-3 with high affinity (Ki=1-5.5 nM), inhibits a number of CCR1-mediated effects including Ca(2+) mobilization, increase in extracellular acidification rate, CD11b expression; effectively reduces disease in a rat experimental allergic encephalomyelitis model of multiple sclerosis.Multiple Sclerosis Discontinued.
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In Vitro——
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In Vivo——
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SynonymsBX-471 hydrochloride | BX 471 hydrochloride
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaInflammation/Immunology
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IndicationMultiple Sclerosis
Chemical Information
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CAS Number288262-96-4
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Formula Weight471.3526
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Molecular FormulaC21H25Cl2FN4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F.Cl
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Chemical NameUrea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Horuk R, et al. J Biol Chem. 2001 Feb 9;276(6):4199-204.
2. Anders HJ, et al. J Clin Invest. 2002 Jan;109(2):251-9.
3. Strasly M, et al. Blood. 2004 Jan 1;103(1):40-9.
4. Liang M, et al. J Biol Chem. 2000 Jun 23;275(25):19000-8.
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